Serum and Peritoneal Fluid Levels of Vascular Endothelial Growth Factor in Women with Endometriosis
نویسندگان
چکیده
BACKGROUND Endometriosis is known as one of the most common disease in women of reproductive age. Due to important role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell, and also presence of different studies reported VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF levels of VEGF in endometriosis patients, and to compare with normal subjects. MATERIALS AND METHODS In this descriptive study, 179 women subjected to laparoscopy for the evaluation of infertility or pelvic pain were allocated into the following two groups: group I: different types of endometriosis patients (n=90) and group II: non-endometriosis patients (n=89). The PF from pelvis and venous blood samples were obtained. The VEGF concentration of the serum and PF were measured using enzyme immunoassay kit and were compared using t test. RESULTS The level of VEGF in serum was significantly less than that in PF in both groups (p=0.00). However, endometriosis patients had significantly higher level of VEGF in peritoneal fluid than non-endometriosis patients (p=0.043). CONCLUSION According to our findings, endometriosis is not associated with change in the level of circulating VEGF.
منابع مشابه
Serum and Peritoneal Fluid Levels of Vascular Endothelial Growth Factor in Women with Endometriosis
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Received: 17 Aug 2013, Accepted: 9 Oct 2013 * Corresponding Address: Department of Obstetrics and Gynecology, San Martino Hospital and National Institute for Cancer Research, University of Genoa, 16132 Genoa, Italy Email: [email protected] Royan Institute International Journal of Fertility and Sterility Vol 8, No 4, Jan-Mar 2015, Pages: 485-486 We read with interest the manuscript entitled "Serum ...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2013